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Additional info for Toxicological profiles - Hydraulic fluids
However, chickens have been shown to be a sensitive species for neurological effects, and data from chickens are included in both the LSE tables and figures. Respiratory Effects. Mineral Oil Hydraulic Fluids. No studies were located regarding respiratory effects in humans after inhalation exposure to mineral oil hydraulic fluids. 0 mg/m3 of the water-in-oil emulsion hydraulic fluid Houghto-Safe 5047F for 90 days, 23 hours/day, showed no treatment-related lesions (Kinkead et al. 1991). Organophosphate Ester Hydraulic Fluids.
Military fluids Durad MP280 and Fyrquel 220 produced no adverse respiratory effects in male Sprague-Dawley rats at respective concentrations of 6,190 and 5,790 mg/m3 and female Sprague-Dawley rats exposed to 6,350 and 6,310 mg/m3, respectively (Gaworski et al. 1986; Kinkead et al. 1992a). 6,300 mg/m3 of Fyrquel 220 (Gaworski et al. 1986; Kinkead et al. 1992a) or Durad MP280 (Gaworski et al. 1986) did not result in respiratory tract damage in rats. Following intermediate-duration exposure to organophosphate ester hydraulic fluids, reversible rapid respirations were observed in rabbits exposed to 2,000 mg/m3 of a triaryl phosphate hydraulic fluid (Cellulube 220) (Carpenter et al.
1985). In these experiments, rats were observed for 14 days after exposure. 3 Immunological and Lymphoreticular Effects Mineral Oil Hydraulic Fluids. No studies were located regarding immunological effects in humans or animals after inhalation exposure to mineral oil hydraulic fluids. Organophosphate Ester Hydraulic Fluids. No studies were located regarding immunological effects in humans after inhalation exposure to organophosphate ester hydraulic fluids. Information regarding immunological effects in animals is restricted to histopathological examination of organs with immune functions (thymus, spleen, lymph nodes) after intermediate-duration inhalation exposures of up to 90 days.