By Daniel Erik Otzen
Summing up nearly a decade of biomedical study, this topical and eagerly awaited guide is the 1st reference at the subject to include contemporary breakthroughs in amyloid learn.
the 1st half covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, together with an outline of present versions for amyloid formation. the second one half seems to be on the prognosis and biomedical research of amyloid in people and in animal versions, whereas the ultimate part discusses pharmacological techniques to manipulating amyloid and likewise appears to be like at its physiological roles in reduce and better organisms.
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Extra info for Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties
2002) Getting out of shape. Nature, 418, 729–730. W. (2005) Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Acc. Chem. , 38, 911–921. References 52. , 53. 54. 55. 56. W. (2003) Benzoxazoles as transthyretin amyloid ﬁbril inhibitors: synthesis, evaluation, and mechanism of action. Angew. Chem. Int. , 42, 2758–2761. Dumoulin, M. M. (2005) Probing the origins, diagnosis and treatment of amyloid disease using antibodies.
15 16 1 The Amyloid Phenomenon and Its Signiﬁcance Acknowledgments I would like to acknowledge the many graduate students, post-doctoral fellows, colleagues, and collaborators whose discoveries and ideas are reﬂected in this chapter, many of whose names appear in the citations to published work. I am also very grateful to the many organizations who have funded our research over many years including the Wellcome Trust, the Leverhulme Trust, the Alzheimer’s Research Trust, Parkinson’s UK, the European Commission, UK Research Councils (EPSRC, BBSRC and MRC), and Elan Pharmaceuticals.
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