Carol Bernstein, Harris Bernstein's Aging, Sex, and DNA Repair PDF

By Carol Bernstein, Harris Bernstein

Why organisms age and why sexual copy exists are significant unsolved difficulties in biology. This e-book presents an built-in rationalization of getting older and intercourse according to present wisdom of DNA harm and service. Key gains* Discusses the universality of the matter of DNA harm* Describes getting older by reason of amassed DNA harm* Considers meiosis as an edition for DNA fix* Discusses mating in Read more...

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Example text

F o r instance, calf t h y m u s D N A , modified by a dihydrodiol epoxide derivative of benzo(a)pyrene, has been shown to be less efficiently transcribed in vitro by E. , 1977). In these e x p e r i m e n t s , the R N A transcripts decreased progressively in chain length as the extent of D N A modification increased. In a different study, rat hepatic D N A , treated with iV-acetoxy-2-acetylaminofluorene, also was much less effective as a template for R N A transcription (Zieve, 1973). , 1976; Arrand and M u r r a y , 1982).

E a c h nuclease gave similar results. T h e lengths of the double-stranded pieces obtained after nuclease treatment w e r e determined from electron micrographs. The average molecular weight of the double-stranded D N A between two singlestrand b r e a k s w a s determined by measuring 20-200 molecules for each individual. T h e 470 individuals contributing to the data were 1-91 yr old. It w a s found that the average molecular weight of the double-stranded D N A between t w o single-strand breaks significantly d e c r e a s e s with age.

1984), using alkaline sucrose sedimentation to measure single-strand b r e a k s , found that D N A damage did not measurably a c c u m u l a t e in m o u s e brain tissue with age. A similar lack of accumulation of single-strand b r e a k s in rat brain was found by Mullaart et al. (1990) using the technique of alkaline elution.

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